Application of Synthetic Polymeric Scaffolds in Breast Cancer 3D Tissue Cultures and Animal Tumor Models

Figure 4

Support of the polymeric scaffolds for tumor formation in mice. Blank porous PLGA scaffolds (without MDA-MB-231 cells) and MDA-MB-231 cell-laden PLGA scaffolds were implanted into the mammary fat pads of the mice. Tumor growth were dynamically observed using IVIS during 4 weeks of the period ((a) and (f)). The cross sections of the tumors collected at the end point of the experiments were stained for DAPI (blue, (b) and (g)), Ki-67 (green, (c) and (h)), and HER2 (red, (d) and (i)). Scale bars, 100 m.