Table of Contents Author Guidelines Submit a Manuscript
International Journal of Biomaterials
Volume 2017 (2017), Article ID 8234712, 7 pages
https://doi.org/10.1155/2017/8234712
Research Article

Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel

1Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City, Vietnam
2Can Tho University, 3/2 Street, Ninh Kieu District, Can Tho City, Vietnam
3Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), Ho Chi Minh City 70000, Vietnam

Correspondence should be addressed to Dai Hai Nguyen; moc.liamg@1150iahiadneyugn

Received 3 January 2017; Revised 7 February 2017; Accepted 9 February 2017; Published 26 February 2017

Academic Editor: Fahima Dilnawaz

Copyright © 2017 Thi Lan Nguyen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of  nm. Besides, PTX was efficiently encapsulated in Lips, % for drug loading efficiency, and slowly released up to 96 h, compared with free PTX. More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.