Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments
Table 2
Substance classification criterion tested according to GHS/OECD parameters.
Classification
Criterion
Irritative (Category 2)
(1) Average of ≥2.3 ≤ 4.0 for erythema/eschar or for edema in at least 2 of the 3 animals tested at 24 hours, 48 hours, and 72 hours after removing the patch, or if the reactions are delayed, for classifications in 3 consecutive days after the appearance of skin reactions, or (2) inflammation that persists at the end of the observation period, normally 14 days and in at least 2 animals, particularly taking into account alopecia (defined area) hyperkeratosis, hyperplasia, and flaking, or (3) in some cases when there is a pronounced response variability between the animals, with well-defined positive effects related to the exposure chemical in an animal but less than the previous criteria
Medium irritant (Category 3)
Average of ≥1.5 < 2.3 for erythema/eschar or for edema in at least 2 of the 3 animals tested at 24 hours, 48 hours, and 72 hours or, if the reactions are delayed, for ratings on 3 consecutive days after the onset of skin reactions (when they are not included in the previous category of irritation)
