Microenvironment Influence of a Novel Bioengineered Wound Product, APIS®: A Preliminary In Vitro Analysis of Inflammatory Marker and Growth Factor Secretion

Table 2

Proteins detected using cytokine array assay.

Name	Description
CHI3L1	Chitinase 3-like 1; secreted by activated macrophages [39]
Complement factor D	Part of the alternative complement pathway [40]
Emmprin	Extracellular matrix metalloproteinase inducer; induces synthesis of several MMPs [41]
Endoglin	Transmembrane glycoprotein; expressed by monocytes transitioning to macrophages [42]
GDF-15	Growth/differentiation factor 15; stress responsive cytokine [43]
GROα	Growth-regulated alpha protein; chemotactic for neutrophils [44]
IL-8	Interleukin-8; chemotactic for neutrophils [45]
MIF	Macrophage migration inhibitory factor; inflammatory cytokine [46]
MIP-1α/β	Macrophage inflammatory proteins; chemotactic and proinflammatory; produced by macrophages in response to bacterial endotoxins [47]
MIP-3β	Macrophage inflammatory protein 3 alpha; chemotactic [48]
MMP-9	Matrix metallopeptidase 9; involved in degradation of the extracellular matrix [49]
Osteopontin	Upregulated during macrophage differentiation; known to be induced in macrophages by inflammatory cytokines [50]
PDGF-AA	Platelet-derived growth factor; regulates cell growth and division; produced by macrophages in the wound healing stage [51]
RANTES	Regulated on activation, normal T cell expressed and secreted; chemotactic [52]
uPAR	Urokinase-type plasminogen activator receptor; role in plasminogen activation [53]