Microenvironment Influence of a Novel Bioengineered Wound Product, APIS®: A Preliminary In Vitro Analysis of Inflammatory Marker and Growth Factor Secretion

Table 3

Description of growth factors targeted in ELISA.

Name	Description
VEGF	Vascular endothelial growth factor; mediates vascular growth and angiogenesis [59]; encourages collagen deposition and epithelialization in wound healing [60]
EGF	Epidermal growth factor; mediates cellular proliferation, differentiation, and survival [61]
PDGF-BB	Platelet derived growth factor; mitogen for several cell types including fibroblasts and smooth muscle cells [62]
SCF	Stem cell factor; hematopoietic cytokine [63]
TNFα	Tumor necrosis factor alpha; acute inflammatory cytokine that plays a role in immunostimulation and resistance to infectious agents and tumors [57, 64]
FGFb	Basic fibroblast growth factor; important in the development and function of numerous organ systems. Some effects include stimulating smooth muscle cell growth, wound healing, and tissue repair [65]
TGFβ	Transforming growth factor beta; multifunctional growth factor that plays important role in growth and development, inflammation and repair, and immunity [66]