On the Genesis of Neuroblastoma and Glioma

Table 1

International Neuroblastoma Staging System (INSS).

1	Localized tumour with complete gross excision, with or without microscopic residual disease; representative ipsilateral lymph nodes negative for tumour microscopically (nodes attached to and removed with primary tumour may be positive)
2A	Localized tumour with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumour microscopically
2B	Localized tumour with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumour; enlarged contralateral lymph nodes must be negative microscopically
3	Unresectable unilateral tumour infiltrating across the midline, with or without regional lymph node involvement; localized unilateral tumour with contralateral regional lymph node involvement; or midline tumour with bilateral extension by infiltration (unresectable) or by lymph node involvement
4	Any primary tumour with dissemination to distant lymph nodes, bone marrow, bone, liver, skin, and/or other organs (except as defined for stage 4S)
4S	Localized primary tumour (as defined for stage 1, 2A, or 2B), with dissemination limited to skin, liver, and/or bone marrow (limited to infants less than 1 year of age)