International Journal of Cell Biology / 2010 / Article / Fig 1

Review Article

Cellular Stress Responses: Cell Survival and Cell Death

Figure 1

Induction of heat shock proteins inhibits apoptosis and promotes cell survival. Exposure of cells to elevated temperatures, oxidative stress, and heavy metals causes accumulation of unfolded proteins, which through activation of HSF1 leads to induction of Hsp27 and Hsp70. These Hsps inhibit apoptosis and promote survival.

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