Contribution of Filopodia to Cell Migration: A Mechanical Link between Protrusion and Contraction
Figure 2
Filopodial behavior during cell migration followed by leading edge retraction. (a) High magnification image sequences of B16F1 cell transiently transfected with mCherry-actin. The projection of filopodia beyond the edge of the lamellipodium followed by retraction of the leading edge. The entire movie can be found in Supplementary Data, Movie 1. (b) Cell retraction, speed and filopodial behavior over three time periods. Light blue, pink and turquoise represent speed of nucleus displacement, lamellipodial protrusion and filopodial elongation, respectively. The frame position is locked so movement toward the edge represents lamellar extension/retraction. Scale Bar 10 m.
