Contribution of Filopodia to Cell Migration: A Mechanical Link between Protrusion and Contraction
Figure 6
Lateral filopodia and myosin II play important roles in actin-arc formation. (a) Live cell time-lapse of B16F1 cell cotransfected with mCherry-actin and myosin II-GFP. The white arrow shows the direction of cell migration. Turquoise arrowheads show the association of myosin II to filopodia. White arrowheads show the fusion of two converging lateral filopodia. The thick blue line indicates the original position of the leading edge at . The insets show a zoomed in view of the same field. Myosin II associated with the proximal ends of lateral filopodia which subsequently merged and moved into the cell body. The entire movie can be found in Supplementary Data, Movie 4. Scale Bar 10 m.
