Contribution of Filopodia to Cell Migration: A Mechanical Link between Protrusion and Contraction

Figure 8

The lateral motion of filopodia is related to the direction of cell migration. Live cell time-lapse of a cell transfected with mCherry-T-plastin. Turquoise arrowheads indicate the lateral filopodia. The golden arrow shows the direction of movement of the original lamellipodium and the white arrow shows the direction of eventual cell migration. The last panel shows a Z-projection of all the images to visualize the track of the nucleus (red line) and the track of the lateral filopodium. The lateral filopodium moves in a direction opposite to the direction of cell turning. The entire movie can be found in Supplementary Data, Movie 9. Scale Bar 10 𝜇m.