Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery

Figure 2

Diagram showing effects of dietary KAT and HDAC inhibition. The capital letter K (in red) refers to a lysine residue and Ac in green refers to acetylation. Different dietary components act on distinct KATs and HDACs to produce differential cellular effects depending on cell types and conditions. On the KAT and HDAC modulators illustrated here, all are small molecules except lunasin and MCP30, which are a 43-residue polypeptide and a 30 kDa protein, respectively. In addition to the inhibitors illustrated here, KAT and HDAC activators, as well as dietary patterns (such as high fat diet, high salt ingestion, and calorie restriction) and environmental factors, may target the acetylation machinery.