Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery
Figure 3
Chemical structure of naturally occurring KAT inhibitors. (a) Anacardic acid from cashew nut shell extracts; (b) garcinol from Garcinia indica fruit rind; (c) curcumin from Curcuma longa rhizome; (d) plumbagin from Plumbago rosea root extracts; and (e) spermidine as an endogenous molecule [28, 32, 33]. Some of these compounds have been modified to synthesize more enzyme-specific inhibitors, which are not depicted here [34, 35].
