Gaucher Disease and Cancer: Concept and Controversy

Table 1

Examples of reported associations of Gaucher disease with multiple myeloma. *Note: the number in the bracket represents the reference number in the current Choy and Campbell publication.

Date	Title	Authors
1965	Coincidence of multiple myeloma with Gaucher disease	Pinkhas et al. [15]*
1968	Immunoglobulin anomalies in Gaucher disease: Report of 16 cases	Pratt et al. [16]
1979	Nonsecretory IgD-kappa multiple myeloma in a patient with Gaucher disease	Benjamin et al. [17]
1980	Coexistence of IgA myeloma and Gaucher disease	Ruestow et al. [18]
1982	Coexistence of Gaucher disease and multiple myeloma	Garfinkel et al. [19]
1988	Sequential appearance of breast carcinoma, multiple myeloma, and Gaucher disease	Gal et al. [20]
1991	Case report: serendipitous Gaucher disease presenting as elevated erythrocyte sedimentation rate due to monoclonal gammopathy	Liel et al. [21]
1993	Increased risk of cancer in patients with Gaucher disease	Shiran et al. [22]
1995	Complex IgA gammopathy in Gaucher disease	Shvidel et al. [23]
1997	Multiple myeloma arising from monoclonal gammopathy of undetermined significance in a patient with Gaucher disease	Brady et al. [24]
2000	Coincidence of Gaucher disease due to a 1226G/1448C mutation and of an immunoglobulin G lambda multiple myeloma with Bence-Jones proteinuria	Harder et al. [25]
2000	Uncommon combination of multiple myeloma in three patients	Mateja et al. [26]
2005	Gaucher disease and cancer incidence: a study from the Gaucher’s Registry	Rosenbloom et al. [27]
2006	Increased incidence of cancer in adult Gaucher disease in Western Europe	De Fost et al. [28]
2009	The underrecognized progressive nature of N370S Gaucher disease and assessment of cancer risk in 403 patients	Taddei et al. [29]
2010	Expanding the spectrum of the association between Type 1 Gaucher disease and cancers: a series of patients with up to 3 sequential cancers of multiple types—correlation with genotype and phenotype	Lo et al. [30]