Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin 𝜷 Subunit to the N-Terminal and C-Terminal Coding Sequence

Table 2

Mean pharmacokinetic parameters following IV administration of a single dose (20 μg/kg) of rHuEPO, EPO-(CTP)₃, and Aranesp in male ICR mice. Parameters were generated for individual rats and the mean data are presented here.

Parameters	rHuEPO	EPO-(CTP)3	Aranesp
AUC (hr*μg/L)	31739	306072	178661
Cmax (μg/L)	10766	16466	13266
Tmax (hr)	0.25	0.25	0.25
T1/2 (α) (hr)	4.4	13.11	10.84