Cellular Reprogramming toward the Erythroid Lineage
Figure 1
Diagrammatic representation of cellular reprogramming compared to transdifferentiation in the development of erythrocytes. (a) Fibroblasts cells can be reprogrammed into pluripotent cells through the introduction of various exogenous factors. From this induced pluripotent state, these cells can be either cultured with various cytokines supporting erythrocyte differentiation and growth, for instance, IL-3, IL-6, and Erythropoietin (Epo) or cultured with OP9 bone marrow stroma cells to differentiate into erythrocytes. (b) Fibroblasts cells can be reprogrammed directly into erythrocytes through the introduction of Oct4 and culturing with Epo in conjunction with other haematopoietic cytokines.
