Acute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb: Involvement of Endocannabinoids—Cannabinoids and Acute Stress Modulate GABA Release

Table 1

Effect of cannabinoids and acute stress on basal 3H-GABA release. Micro dissected EPL was incubated with 0.1 μM 3H-GABA and superfused with Krebs bicarbonate; after 47 min of superfusion a basal release was reached. Basal release is a % of release and was measured as described in methods and is the median with 95% confidence interval of experiments. The abbreviations of the drugs are as described above.

Control	0.50 (0.38–0.65); 𝑛 : 65
AEA, 10 uM	0.41* (0.31–0.53); 𝑛 : 34
Win, 1 uM	0.55^ns (0.38–0.59); 𝑛 : 22
AM281, 10 uM	0.35* (0.3–0.47); 𝑛 : 10
URB597, 250 uM	0.34* (0.31–0.39); 𝑛 : 15
AM 404, 20 uM	0.37* (0.27–0.42); 𝑛 : 16
THL, 0.5 uM	0.94* (0.61–1.06); 𝑛 : 6
2AG, 10 uM	0.53^ns (0.41–0.6); 𝑛 : 26
Acute Stress	0.42^ns (0.36–0.54); 𝑛 : 30