Transplantable Subcutaneous Hepatoma 22a Affects Functional Activity of Resident Tissue Macrophages in Periphery
Figure 7
The influence of tumor growth on blood leukocytes, cytokine serum level, spleen, and thymus. (a)—blood leukocyte (upper curve) and peritoneal cell (lower curve) counts during the growth of hepatoma 22a. (b)—absolute cell numbers of leukocytes in the blood of tumor-bearing mice: polymorphonucleus leukocytes (1), lymphocytes (2), and monocytes (3). (c)—percent of total number of leukocytes: polymorphonucleus leukocytes (1), lymphocytes (2), and monocytes (3). Each point represents average values of 10 mice (M ± SEM), , , compared to control. (d)—serum IL-6 level determined by ELISA, pg/mL. Each bar represents average values of 5 mice (M ± SEM). At every timepoint the data were compared to appropriate control group of mice. In (a)—(d) all data from control mice were combined into groups shown on day 0 (M ± SEM). (e)—spleen weight, mg (2: tumor-bearers, 3: control mice) and total number of nucleated cells per organ, mln (1: control mice, 4: tumor-bearers). (f)—thymus weight, mg (1: tumor-bearers, 2: control mice), and total number of nucleated cells per organ, mln (3: tumor-bearers, 4: control mice). Each point represents average values of 10 mice (M ± SEM).
