ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats
Voltage-Current Relationships in Sham-Operated Control Rats. Sarcolemmal outward potassium current (I), expressed as current density (pA/pF), in patches of ventricular myocytes from adult control rats subjected to a sham surgical operation, treatment with the ATP-sensitive potassium channel (KATP) agonist cromakalim (100 μM), and post-treatment with the KATP antagonist glibenclamide (5 μM). The membrane voltage was clamped at steps of 10 mV from −80 mV to +40 mV. Differences in pA/pF in the presence and absence of treatment with cromakalim, and post-treatment with glibenclamide were significant only at the voltages from −20 mV to +40 mV ().