ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats
Comparison of Effects of Cromakalim and Glibenclamide. Bars represent the sarcolemmal outward potassium current density amplitude, expressed as percentages of the control values of ventricular myocytes from control, sham-operated and shunted, volume-overloaded rats, measured at the clamp voltage of +40 mV under conditions of pretreatment with cromokalim and post-treatment with glibenclamide. Asterisk () indicates statistically significant difference from control and shunt at . Inserts are raw data recordings showing the amplitudes of outward potassium currents (I), expressed in pA, acquired at a membrane clamp voltage of +40 mV during the control condition, pretreatment with cromokalim and post-treatment with glibenclamide; left insert from a sham-operated control and right insert from a shunted volume-overloaded rat.