Insights into the Function of the Unstructured N-Terminal Domain of Proteins 4.1R and 4.1G in Erythropoiesis

Figure 5

Mapping of the CaM-binding sites in 4.1R. 4.1R¹³⁵ has three CaM-binding sites: pep2 in the HP region, S¹⁸⁵ being the key residue for Ca²⁺-sensitive site, and Ca²⁺-independent sequence; pep9 and pep11 in the FERM domain. Numbers in parenthesis indicate amino acid numbering for 4.1R⁸⁰ (AUG2 form in Figure 4).