Stable Differences in Intrinsic Mitochondrial Membrane Potential of Tumor Cell Subpopulations Reflect Phenotypic Heterogeneity

Figure 4

Differences in the intrinsic ΔΨm of subcloned cell lines derived from primary colonic and mammary tumors are linked to phenotypes associated with solid tumor expansion. VEGF was quantified by ELISA in condition medium harvest from SW480 and MCF7 cell lines, and subclones derived from each of the cell lines, and normalized for cells/well by the MTT assay. VEGF secretion levels are plotted as a function of relative ΔΨm.