The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
(a) General schematic representation of an anchoring junction. The scheme depicts the basic organization of the proteins comprising an anchoring junction. The three organizational levels (see text) are represented by different colors; modified from Matter and Balda . (b) Scheme representing some of the interactions between ENaC and the cytoskeleton. The channel is kept in its membrane location via the spectrin-based cytoskeleton. In the nonstimulated state, ENaC is bound to F-actin directly and/or by cortactin-Arp2/3 interaction (left panel). Diverse stimuli promote formation of short actin filaments that activate ENaC by direct binding to the channel (right panel). See main text for references. (c) Scheme representing some of the interactions between the Na+-K+ ATPase (NKA) and the cytoskeleton; modified from Bennett and Healy .
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