Figure 4: MIF receptor signalling and downstream effectors. (a) Schematic model of receptor-mediated MIF signalling involving CD74 and CXCRs. The involvement of the glutamate antiporter xCT (system xc, xCT forms a heterodimer with CD98 as indicated) in CD74/CD44-dependent signalling is proposed, indicated by the dotted arrow. (b) MIF binding partners with link to brain cancer. Note that the indicated MIF-binding partners given in the scheme are far from complete. Abbreviations used: COX2, cyclooxygenase 2; ERK, extracellular signal-regulated kinases; GC, glucocorticoids; GR, glucocorticoid receptor; GEF, guanosine exchange factor; HIF1α, hypoxy Jab1, Jun-activation domain-binding protein-1; MKP1, mitogen-activated protein kinase phosphatases; MMP-9, matrix metallopeptidase or type IV collagenase/gelatinase B; PRDX, peroxiredoxin; Src, sarcoma protooncogene.