International Journal of Cell Biology / 2012 / Article / Tab 2

Review Article

Plastin Family of Actin-Bundling Proteins: Its Functions in Leukocytes, Neurons, Intestines, and Cancer

Table 2

Studies on L-plastin in leukocytes.

Leukocyte typesKey words of the studyReferences

Innate immunity
 MacrophagesBacterial lipopolysaccharide (LPS)-induced activation[810, 12]*, [13, 14]
 MacrophagesGrancalcin and host defence[15]
 MacrophagesIL-1/TNF-induced activation[16]*
 MacrophagesPodosome formation[17]
 MacrophagesZebrafish and lineage marker[1820]
 MacrophagesToxoplasma gondii-infection[21]
 NeutrophilsIL-8-induced activation[22]*
 NeutrophilsFc receptor and phagocytosis[23, 24]*
 NeutrophilsL-plastin KO# and integrin[25, 26]*
 EosinophilsGM-CSF-induced priming[27]*
 OsteoclastsPodosome formation[28]
 OsteoclastsSealing ring formation[29]
Adaptive immunity
 T-cellsIL-2-induced activation[30]*
 T-cellsAccessory receptors[31]*
 T-cellsLymphokine-activated killer cells[32]*
 T-cellsCCR7 and thymus[34]
 T-cellsLFA-1 and immune synapse[35]
 T-cellsL-plastin KO# and impaired T cell responses[36]
 B-cellsMarginal zone B cell development[37]
Suppression immunotherapies targeting L-plastin
 LeukocytesCannabinoid receptor agonists[38]
 LeukocytesGlucocorticoid dexamethasone[39]

*These studies addressed the L-plastin phosphorylation in leukocytes.
#Disruption of the L-plastin gene in mice.

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