Figure 1: Various steps in tumor initiation and progression where panel (a) represents initiation of tumor by transforming normal cells, panel (b) shows the modulation of ECM proteins allowing transformed cells to multiply, panel (c) shows progression of cancer by replacing normal cells, panel (d) represents the invasion, where cancer cells migrate into the blood stream by modulating ECM and cell adhesion molecules, and panels (e) shows metastasis where the cancer cells are localized at different sites enabling angiogenesis.