Treatment with Y-27632, a ROCK Inhibitor, Increases the Proinvasive Nature of SW620 Cells on 3D Collagen Type 1 Matrix
Figure 3
SW620 cells were seeded at densities of 50 × 103 and 250 × 103 cells/cm2 onto Boyden chambers with an 8 μm pore membrane. The wells were treated with Y-27632 to study the impact of ROCK inhibition on cell invasion in a low- and high-density environment. A 3.5-fold increase in cell invasion was observed in Y-27632-treated cells seeded at a lower density of 50 × 103 cells/cm2.
