Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis

Figure 2

Schematic representation of EMT and anoikis resistance. EMT-inducing factors, such as TGF-β and FGF activate transcriptional factor, Twist, Snail and Zeb1. Activated these transcriptional factors repress E-cadherin (encoded CDH1 gene) expression and induce N-cadherin expression (Cadherin switch). Cadherin switch induces EMT and anoikis resistance, which are associated with tumor metastasis.