Review Article
The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis
Table 1
The role of IgSF members in the metastatic cascade.
| Stages in metastasis | Involvement of IgSF members | Known role | Potential role |
| (1) Cell proliferation in primary tumour | | | (i) Apoptotic | NCAM [24] | MCAM [27, 28] | evasion | ALCAM [29] | (ii) Angiogenesis | PECAM-1 [30, 31] |
VCAM [32] | | ICAM-1 [33, 34] |
| (2) Local cell invasion | | | | MCAM [8, 35, 36] | | (i) Cell-cell | ALCAM [37] | | interactions | L1CAM [14, 38] | | | | ICAM-1 [40] | (ii) Directional cell | | VCAM-1 [40] | migration and cell | MCAM [39] | PECAM-1 [41] | polarity | | NCAM [27] | | | MCAM [25, 42, 43] | L1-CAM [44] | (iii) Matrix | MCAM [35, 36, 45] |
ALCAM [46] | degradation | NCAM [47] |
| (3) Intravasation and dissemination | | MCAM [48] | | ALCAM [49] |
| (4) Extravasation | | MCAM [8, 35, 36] | | ALCAM [14, 37] | | NCAM [50] | | L1CAM [38, 51, 52] | | PECAM-1 [53, 54] |
| (5) Colonization and proliferation | As for (1) and (2) | As for (1) and (2) |
| (6) Immunological escape | | MCAM [8, 36] | | ALCAM [14, 37] | | NCAM [50] |
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