International Journal of Cell Biology / 2012 / Article / Tab 1

Review Article

The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis

Table 1

The role of IgSF members in the metastatic cascade.

Stages in metastasis Involvement of IgSF members
Known role Potential role

(1) Cell proliferation in primary tumour
 (i) Apoptotic  NCAM [24]MCAM [27, 28]
evasionALCAM [29]
 (ii) AngiogenesisPECAM-1 [30, 31] VCAM [32]
ICAM-1 [33, 34]

(2) Local cell invasion
MCAM [8, 35, 36]
 (i) Cell-cellALCAM [37]
interactionsL1CAM [14, 38]
ICAM-1 [40]
 (ii) Directional cellVCAM-1 [40]
migration and cellMCAM [39]PECAM-1 [41]
polarityNCAM [27]
MCAM [25, 42, 43]
L1-CAM [44]
 (iii) MatrixMCAM [35, 36, 45] ALCAM [46]
degradationNCAM [47]

(3) Intravasation and disseminationMCAM [48]
ALCAM [49]

(4) ExtravasationMCAM [8, 35, 36]
ALCAM [14, 37]
NCAM [50]
L1CAM [38, 51, 52]
PECAM-1 [53, 54]

(5) Colonization and proliferationAs for (1) and (2)As for (1) and (2)

(6) Immunological escapeMCAM [8, 36]
ALCAM [14, 37]
NCAM [50]

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