Research Article
Paternal Benzo[a]pyrene Exposure Modulates MicroRNA Expression Patterns in the Developing Mouse Embryo
Table 1
Expression levels of the six up- and down-regulated miRNAs in developing embryos derived from B[a]P exposed fathers, relative to unexposed controls.
| miRNA | Direction | 2-cell | 8-cell | Blastocyst | # target genes(a) |
| mmu-miR-574-5p | Up | 2.73 | 2.00 | 1.91 | 531 | mmu-miR-467f | Up | 5.83 | 1.23 | 2.23 | 972 | mmu-miR-294 | Up | 3.22 | 1.74 | 1.19 | 646 | mmu-miR-210 | Up | 2.27 | 1.26 | 2.48 | 127 | mmu-miR-197 | Up | 1.91 | 2.41 | 1.80 | 379 | mmu-miR-139-3p | Up | 4.33 | 2.56 | 1.93 | 333 |
| mmu-miR-99a | Down | −1.29 | −2.56 | −0.56 | 64 | mmu-miR-483 | Down | −0.39 | −1.23 | −13.45 | 107 | mmu-miR-466f-5p | Down | −4.40 | −2.86 | −2.08 | 318 | mmu-miR-346 | Down | −4.16 | −2.04 | −0.32 | 453 | mmu-miR-1906 | Down | −4.63 | −1.38 | −1.03 | 615 | mmu-miR-1896 | Down | −6.18 | −4.94 | −3.06 | 638 |
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Note: Log2-transformed ratio of B[a]P and control; (a) predicted targets.
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