Paternal Benzo[a]pyrene Exposure Modulates MicroRNA Expression Patterns in the Developing Mouse Embryo

Table 1

Expression levels of the six up- and down-regulated miRNAs in developing embryos derived from B[a]P exposed fathers, relative to unexposed controls.

miRNA	Direction	2-cell	8-cell	Blastocyst	# target genes^(a)
mmu-miR-574-5p	Up	2.73	2.00	1.91	531
mmu-miR-467f	Up	5.83	1.23	2.23	972
mmu-miR-294	Up	3.22	1.74	1.19	646
mmu-miR-210	Up	2.27	1.26	2.48	127
mmu-miR-197	Up	1.91	2.41	1.80	379
mmu-miR-139-3p	Up	4.33	2.56	1.93	333
mmu-miR-99a	Down	−1.29	−2.56	−0.56	64
mmu-miR-483	Down	−0.39	−1.23	−13.45	107
mmu-miR-466f-5p	Down	−4.40	−2.86	−2.08	318
mmu-miR-346	Down	−4.16	−2.04	−0.32	453
mmu-miR-1906	Down	−4.63	−1.38	−1.03	615
mmu-miR-1896	Down	−6.18	−4.94	−3.06	638

Note: Log2-transformed ratio of B[a]P and control; ^(a) predicted targets.