Paternal Benzo[a]pyrene Exposure Modulates MicroRNA Expression Patterns in the Developing Mouse Embryo

Table 2

Number of targets genes in enriched KEGG pathways for the six up-regulated and the six down-regulated genes.

(a) Six upregulated miRNAs

Enriched KEGG pathways	Selected dysregulated miRNAs
	mmu-miR-139-3p	mmu-miR-197	mmu-miR-210	mmu-miR-294	mmu-miR-467f	mmu-miR-574-5p
Metabolic pathways	37	27	8	32	47	28
Cytokine-cytokine receptor interaction		7		11	23
Insulin signaling pathway				9	14	11
Pathways in cancer				16	22	15
Regulation of actin cytoskeleton		6		16		13
Apoptosis		4		8
MAPK signaling pathway				16		13
Pancreatic cancer			2			8

(b) Six downregulated miRNAs

Enriched KEGG pathways	Selected dysregulated miRNAs
	mmu-miR-1896	mmu-miR-1906	mmu-miR-346	mmu-miR-466f-5p	mmu-miR-483	mmu-miR-99a
Metabolic pathways	54	40	23	7	7	7
Pathways in cancer		14	10	4		2
Cell cycle				3	2	2
Neuroactive ligand-receptor interaction		13	9	5
TGF-beta signaling pathway			6	3	2
Calcium signaling pathway	12	11
Chemokine signaling pathway	11				2
Glycerophospholipid metabolism		7				3
Leukocyte transendothelial migration	8	9
Melanogenesis				3	2
Progesterone-mediated oocyte maturation			5		2

Note: number of target genes for particular miRNA that are enriched in particular KEGG pathway.