Research Article
Paternal Benzo[a]pyrene Exposure Modulates MicroRNA Expression Patterns in the Developing Mouse Embryo
Table 2
Number of targets genes in enriched KEGG pathways for the six up-regulated and the six down-regulated genes.
(a) Six upregulated miRNAs |
| Enriched KEGG pathways | Selected dysregulated miRNAs | mmu-miR-139-3p | mmu-miR-197 | mmu-miR-210 | mmu-miR-294 | mmu-miR-467f | mmu-miR-574-5p |
| Metabolic pathways | 37 | 27 | 8 | 32 | 47 | 28 | Cytokine-cytokine receptor interaction | | 7 | | 11 | 23 | | Insulin signaling pathway | | | | 9 | 14 | 11 | Pathways in cancer | | | | 16 | 22 | 15 | Regulation of actin cytoskeleton | | 6 | | 16 | | 13 | Apoptosis | | 4 | | 8 | | | MAPK signaling pathway | | | | 16 | | 13 | Pancreatic cancer | | | 2 | | | 8 |
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(b) Six downregulated miRNAs |
| Enriched KEGG pathways | Selected dysregulated miRNAs | mmu-miR-1896 | mmu-miR-1906 | mmu-miR-346 | mmu-miR-466f-5p | mmu-miR-483 | mmu-miR-99a |
| Metabolic pathways | 54 | 40 | 23 | 7 | 7 | 7 | Pathways in cancer | | 14 | 10 | 4 | | 2 | Cell cycle | | | | 3 | 2 | 2 | Neuroactive ligand-receptor interaction | | 13 | 9 | 5 | | | TGF-beta signaling pathway | | | 6 | 3 | 2 | | Calcium signaling pathway | 12 | 11 | | | | | Chemokine signaling pathway | 11 | | | | 2 | | Glycerophospholipid metabolism | | 7 | | | | 3 | Leukocyte transendothelial migration | 8 | 9 | | | | | Melanogenesis | | | | 3 | 2 | | Progesterone-mediated oocyte maturation | | | 5 | | 2 | |
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Note: number of target genes for particular miRNA that are enriched in particular KEGG pathway.
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