The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis
Figure 1
Interplay between Nrf2 and the selenoproteins thioredoxin reductase-1 (TrxR1) and glutathione peroxidase-2 (GPx2). (a) In the presence of selenium, the activation of Nrf2 leads to increased mRNA of both enzymes which can be translated into respective proteins. (b) Under selenium deficiency, Nrf2 is activated which in principle can lead to an induction of TrxR1 and GPx2 mRNA. Due to lack of selenium, the proteins cannot be synthesized. Decrease in TrxR1 further activates Nrf2, which subsequently upregulates enzymes of the glutathione (GSH) system. These, in part at least, can compensate the reduced TrxR1 activity. For details see text.
