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International Journal of Cell Biology
Volume 2012, Article ID 501962, 12 pages
http://dx.doi.org/10.1155/2012/501962
Review Article

Macrophage Migration and Its Regulation by CSF-1

School of Medicine and Pharmacology, The University of Western Australia, M510, 35 Stirling Highway, Crawley, WA 6009, Australia

Received 6 September 2011; Revised 4 November 2011; Accepted 4 November 2011

Academic Editor: Wiljan J. A. J. Hendriks

Copyright © 2012 Fiona J. Pixley. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Macrophages are terminally differentiated cells of the mononuclear phagocytic lineage and develop under the stimulus of their primary growth and differentiation factor, CSF-1. Although they differentiate into heterogeneous populations, depending upon their tissue of residence, motility is an important aspect of their function. To facilitate their migration through tissues, macrophages express a unique range of adhesion and cytoskeletal proteins. Notably, macrophages do not form large, stable adhesions or actin stress fibers but rely on small, short lived point contacts, focal complexes and podosomes for traction. Thus, macrophages are built to respond rapidly to migratory stimuli. As well as triggering growth and differentiation, CSF-1 is also a chemokine that regulates macrophage migration via activation the CSF-1 receptor tyrosine kinase. CSF-1R autophosphorylation of several intracellular tyrosine residues leads to association and activation of many downstream signaling molecules. However, phosphorylation of just one residue, Y721, mediates association of PI3K with the receptor to activate the major motility signaling pathways in macrophages. Dissection of these pathways will identify drug targets for the inhibition of diseases in which macrophages contribute to adverse outcomes.