Table of Contents Author Guidelines Submit a Manuscript
International Journal of Cell Biology
Volume 2012, Article ID 596589, 5 pages
Review Article

Transmission Electron Microscopy Studies of Cellular Responses to Entry of Virions: One Kind of Natural Nanobiomaterial

1Markey Center for Structural Biology, Purdue University, West Lafayette, IN 47907, USA
2Guangzhou East Campus Lab Center, Sun Yat-sen University, Guangzhou 510006, China
3Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
4University of Miami School of Medicine, Miami, FL 33136, USA
5State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China

Received 1 October 2011; Accepted 23 January 2012

Academic Editor: Guoping Chen

Copyright © 2012 Zheng Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Virions are one kind of nanoscale pathogen and are able to infect living cells of animals, plants, and bacteria. The infection is an intrinsic property of the virions, and the biological process provides a good model for studying how these nanoparticles enter into cells. During the infection, the viruses employ different strategies to which the cells have developed respective responses. For this paper, we chose Bombyx mori cypovirus 1 (BmCPV-1) interactions with midgut cells from silkworm, and severe acute respiratory syndrome (SARS) associated coronavirus interactions with Vero E6 cells, as examples to demonstrate the response of eukaryotic cells to two different types of virus from our previous studies. The bacteriophage-bacteria interactions are also introduced to elucidate how the bacteriophage conquers the barrier of cell walls in the prokaryotic cells to transport genome into the host.