KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts

Table 1

Overview of KSHV miRNAs regulatory functions and targets.

Functions	KSHV miRNAs	Validated targets	References
KSHV entry	miR-K12-1	—	[20]
	miR-K12-9	—	[20]
	miR-K12-11	BACH-1	[20, 22, 23]
Induction of reactive nitrogen species (RNS)	miR-K12-1, 9 and 11	—	[20]
Endothelial cell reprogramming	miR-K12-6 and 11	MAF	[24]
KSHV gene expression	miR-K12-7	RTA	[37]
	miR-K12-9	RTA/BCLAF1	[38, 39]
	miR-K12-4	Rbl2	[40]
	miR-K12-1	IκBα	[41]
	miR-K12-3	Nuclear factor I/B	[42]
	miR-K12-5	BCLAF1	[39]
	miR-K12-11	IKKε	[43]
	miR-K12-10 and 12	—	[18]
Cytokine secretion	miR-K12-3 and 7	—	[44]
	miR-K12-11	C/EBPβ	[45]
	miR-K12-10	TWEAKR	[46]
Immune escape	miR-K12-7	MICB	[47]
Cell survival	miR-K12-10	TWEAKR	[46]
	miR-K12-1	p21	[48]