Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease

Figure 1

Mutations in HTRA2 associated with Parkinson’s disease lie in close proximity to p38 and CDK5 phosphorylation sites. Mutations in the amino-terminus (A141S [6] and P143A [18]) and the PDZ domain (G399S [6] and R404W [19]) are indicated. The relative positions of the phosphorylation sites in human HTRA2 (see [20, 21]) are indicated by the circles above the serine residues. A sequence alignment with HTRA2 orthologues from several species is shown.