Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C: Implication of β1-Integrin Activation

Figure 4

Adhesion of K562 cells to FN through α5β1 integrin activation. (a) Dose dependency of TNIIIA2-induced adhesion of K562 cells. (b) Effects of antagonist for VLA5 (α-α5 Ab and RGD) and VLA4 (α-α4 Ab and CS-1) on TNIIIA2-induced adhesion to FN in K562 cells (figures were modified from Figure 1 of [45]). *𝑃<0.05 versus untreated control, **𝑃<0.05 versus TNIIIA2 single treated sample.

(a)

(b)