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International Journal of Cell Biology
Volume 2012, Article ID 703164, 8 pages
Review Article

Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration

Center on Aging, School of Psychological and Behavioral Sciences, University of West Florida, 11000 University Parkway, Pensacola, FL 32514, USA

Received 21 March 2012; Accepted 10 May 2012

Academic Editor: Pier Giorgio Mastroberardino

Copyright © 2012 Rodney P. Guttmann and Tamara J. Powell. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Evidence of increased oxidative stress has been found in various neurodegenerative diseases and conditions. While it is unclear whether oxidative stress is a cause or effect, protein, lipid, and DNA have all been found to be susceptible to oxidant-induced modifications that alter their function. Results of clinical trials based on the oxidative-stress theory have been mixed, though data continues to indicate that prevention of high levels of oxidative stress is beneficial for health and increases longevity. Due to the highly reactive nature of the sulfhydryl group, the focus of this paper is on the impact of oxidative stress on cysteine-dependent enzymes and how oxidative stress may contribute to neurological dysfunction through this selected group of proteins.