Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion

Table 1

Prostaglandins in cancer cell adhesion, migration, and invasion summary table.

Adhesive factor	Tissue	PG	Biological effect	Refs
Cadherins
↓E-cadherin	RIE-S	↑PGE2	COX-2-mediated PGE2 production in rat intestinal epithelial cells (RIE) downregulates E-cadherin	[88]
↓E-cadherin	SCC	↑PGE2	Downregulates E-cadherin through the EP2 receptor during squamous cell carcinoma (SCC) progression	[53]
↑E-cadherin	NSCLC	↓PGE2	S-valproate and S-diclofenac increased E-cadherin but reduced vimentin and ZEB1	[84]
↓E-cadherin	TCC	↑PGE2	Reciprocal correlation between cyclooxygenase-2 expression and E-cadherin in human bladder transitional cell carcinoma (TCC).	[85, 87]
↑E-cadherin	Melanoma	↑PGE2	Decrease of TGFβ1-induced EMT properties in Madin-Darby canine kidney (MDCK) cells is associated with regaining E-cadherin expression	[257]
↑E-cadherin	MDCK	↑PGD2	Decrease of TGFβ1-induced EMT properties in MDCK cells is associated with regaining E-cadherin expression	[258]
↓VE-cadherin	HLVE	↓PGI2	Inhibition of PGI2-mediated human lung vascular endothelial cell (HLVE) responses decreased VE-cadherin expression and increased eosinophil adhesion	[259]
Focal adhesions
↑Actin bundles	HeLa	↑PGE2	Examination of cyclooxygenase-dependent actin bundles in HeLa cells.	[144]
CREB activation	Raw264.7	↑COX2	Examination of Col-I on the COX-2 expression and the signaling pathways in macrophages.	[145]
↑Focal adhesions	Osteoblasts	↑COX2	Focal adhesion promotes fluid shear stress induction of COX-2 and PGE2 release in osteoblasts	[146–148]
↑Focal adhesions	293-EBNA-HEK	↑PGF2α	Regulates Rho-mediated morphological changes	[150, 151]
Integrins
𝛼2𝛽1	Caco-2	↑LTD4/↑PGE2	Increased adhesion to collagen I.	[177]
𝛽1	HT-29	↓PGE2	Decreased adhesion and migration on extracellular matrix	[178]
𝛼3	Mammary TC	↓PGE2	Decreased adhesion to laminin	[179]
𝛼5𝛽1	HLC	↑PGE2	Increased adhesion of human lung carcinoma (HLC) cells to fibronectin	[180]
αIIb𝛽3	B16a melanoma	↑12-HETE	Increased adhesion to fibronectin, endothelial cells, and endothelial cell matrix	[182, 183]