Mitochondrial Dynamics in Cancer and Neurodegenerative and Neuroinflammatory Diseases

Table 3

Mitochondrial dynamics and neuroinflammatory and autoimmune diseases.

Pathology	Proteins involved; (expression level and/or mutation)	Mitochondrial phenotype	Mechanisms of pathophysiology involving mitochondria
Multiple sclerosis	OPA1 mutation	Fragmentation.	Reduction of respiratory rates with lower ATP production [139, 140].
Type 1 diabetes	OPA1 ↓↓; DRP1 ↑↑; PHBs mutation	Fragmentation, disruption of cristae structure.	Alteration in OPA1 processing in β-cells in the pancreas and coronary endothelial cells from diabetic animals [141, 142].