Cytoskeletal Interactions at the Nuclear Envelope Mediated by Nesprins

Figure 6

Illustration of Nesprin interactions at the outer nuclear membrane surface. The inner (INM) and outer (ONM) nuclear membranes are shown to allow simultaneous documentation of the interaction of Nesprins with SUN-domain complexes. Nesprins are aligned along the nuclear envelope. Nesprin-1/-2 ABDs interact with F-actin, N-terminal Nesprin-1 spectrin repeats interact with Nesprin-3, the latter can also interact with the ABD of plectin. Therefore, Nesprins integrate the NE with the major cytoskeletal filaments allowing the formation of a multifunctional Nesprin network along the surface of the ONM. INM located Nesprins have been omitted from this scheme. PNS, perinuclear space.