Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced -Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species
Figure 4
System characteristics under energetic challenge. Energetic demand was varied and behaviour of system variables determined. (a) mitochondrial membrane potential; (b) blue NADH to NAD ratio, red oxygen consumption rate; (c) share of created proton gradient used for ATP synthesis; (d) blue: ubiquinon at p-site, green: ubiquinol at n-site, red: ubiquinon at n-site, black: ubiquinol at p-site. ATP production and oxygen consumption are normalized to the reference state of the system.
