Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced -Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species
Figure 5
Potential ROS producing states in the RC. ROS producing states of complex I ((a) and (b)) and complex III ((c) and (d)) are depicted versus the mitochondrial membrane potential ((a) and (c)) or the ATP production rate. Red: fully reduced flavin, green: flavin radical, blue: semi-ubiquinon at n-site bound to the respective complex, black: semi-ubiquinon at p-site bound to complex III. ATP production and occupation of ROS producing states are normalized to the reference state of the system.
