Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced 𝛼-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

Figure 7

Mitochondrial membrane potential characteristics at inhibition of KGDHC. Mitochondrial membrane potential versus the ATP production rate at different inhibition levels of KGDHC. Dotted line: −80 mV membrane potential level.