Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced 𝛼-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

Figure 8

NADH level characteristics at varying ATP demand and KGDHC inhibition. NADH level is depicted as colour value (right scale). NADH level and ATP production are normalized to the reference state without KGDHC inhibition.