Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced 𝛼-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

Figure 9

NADH level comparison experiment and simulation. Experimental determined NADH level as black points with error bars at different inhibition levels of KGDHC and aconitase (data from [15]). Different coloured curves vary in the basal ATP demand of the system from low (blue) to increased (black). Green curves are for the ATP demand of the reference state. NADH levels are normalized to the NADH level without enzyme inhibition respective to the ATP demand.