Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process
Figure 2
NF-κB signaling controls autophagy via the Beclin 1 interactome. (a) During cellular stress, NF-κB increases the expression of Bcl-2/xL proteins which bind via the NAF-1 to the endoplasmic reticulum and repress the function of the Beclin 1 initiation complex. On the other hand, in some circumstances, NF-κB can inhibit the expression of BNIP3 and oppose the activity of JNK1 which normally dissociates the Beclin 1/Bcl/xL complex (star-head). (b) In proinflammatory conditions, NF-κB signaling increases the expression of several NLRP receptors which can bind to Beclin 1 and this can inhibit autophagocytosis.
