IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells
Figure 1
IQGAP domain structure in yeasts, Dictyostelium discoideum, and mammalian cells. Domain boundaries were determined by MotifScan using Prosite and Pfam sources [2]. (a) IQGAP family members from yeast. The most related members are AgCyk1 31% identical to ScIqg1, CaIqg1 20% identical to ScIqg1 and 24% identical to SpRng2. Note that additional IQ motifs were identified in CaIqg1 and ScIqg1 by visual scanning [3]. (b) IQGAP family members characterized in Dictyostelium discoideum. Percent identify at the amino acid level is shown for each pair. (c) Human IQGAP family members. CHD-calponin homology domain, IR-internal repeats (coiled-coil region), WW-tryptophan containing repeats, IQ-isoleucine and glutamine rich repeats, GRD-GAP-related domain, RGCt-Ras GAP C-terminus homology domain NLS, nuclear localization sequence. Note that not all members of the family contain each domain found in IQGAP1. Although WW domains of other proteins have been shown to bind to proline-rich proteins [4], no such interactions have yet been described for IQGAPs.
