GSK-3𝜷: A Bifunctional Role in Cell Death Pathways

Table 2

Other pro survival roles of GSK-3β.

System	Mechanism
ER stress	Reduces expression of the proapoptotic transcription factor CHOP/GADD153 [87].
Glioblastoma differentiation	Promotes self-renewal through interaction with Bmi1 [81].
Death receptor complex	Inhibits apoptotic signaling and caspase activation [83].
Chemotherapy	Targeted by death-inducing drugs suggesting an inhibitory role [84].
Oncogenic activation	Inhibits apoptotic activation by c-myc [82].
Glucose metabolism	Prevents apoptosis through mitochondrial stabilization [82].